Fibers provide a surface conducive for cellular attachment, growth, and other cellular behaviors that are favorable for bone tissue formation.
Fiber-containing scaffolds are of interest because they mimic the structure of the native collagen matrix in the bone ECM. Bone tissue engineering uses cells and/or growth factors in combination with biomaterials that act as scaffolds to repair bone tissue. However, due to current limitations with bone grafts, autografts, and allografts, bone tissue engineering strategies have been sought. The discovery elucidates a new aspect of material functions, laying the foundation for developing scaffold materials to promote tissue regeneration/repair through guiding the paracrine signaling network. A growing number of customized electrospun fiber scaffolds have been used for drug delivery to facilitate tissue regeneration and cancer therapy. Bone grafts are typically used in these procedures. Our study demonstrates that the fibrous topography of scaffolds is a key material property that modulates the paracrine function of cells. In addition, electrospinning can be used to fabricate porous micro- and nanofibers, as well as various types of hierarchically controlled fibrous structures, ranging from 1 to 3D fibrous scaffolds. each year, for reconstructive surgery, trauma, or abnormal skeletal defects.
This chapter will review bone biology, processing techniques commonly used to prepare fibrous scaffolds, and recent advances using fibrous scaffolds for bone tissue engineering application.ĪB - More than 1 million orthopedic procedures are performed in the U.S. Bone grafts are typically used in these procedures. N2 - More than 1 million orthopedic procedures are performed in the U.S. T1 - Fibrous scaffolds for bone tissue engineering
0 kommentar(er)
